Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

Tau is a microtubule-associated protein which regulates the assembly and stability of microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer's disease (AD). A characteristic of AD tau is hyperphosphorylation wi...

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Bibliographic Details
Main Authors: Taeko Kimura, Govinda Sharma, Koichi Ishiguro, Shin-ichi Hisanaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
phos-tag
tau
phosphorylation
Alzheimer' disease
tauopathy
Cdk5
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00044/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00044/full

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