Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester Hydrochloride Loaded into a Mesoporous Silica

Background: The drug release of antiparkinsonian drugs is an important issue during the formulation process because proper release kinetics can help to reduce the off periods of Parkinson’s disease. A 2-factor, 3-level (3<sup>2</sup>) full-factorial design was conducted to evaluate stati...

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Bibliographic Details
Main Authors: Tamás Kiss, Gábor Katona, László Mérai, László Janovák, Ágota Deák, Gábor Kozma, Zoltán Kónya, Rita Ambrus
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
mesoporous silica
levodopa methyl ester hydrochloride
melevodopa hydrochloride
initial drug release
physical stability
hydrophobization
Online Access:https://www.mdpi.com/1999-4923/13/7/1039

Internet

https://www.mdpi.com/1999-4923/13/7/1039

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