Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Abstract Background Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequ...

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Bibliographic Details
Main Authors: Brian E. Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A. Gharib, Daniel J. Gottlieb, Xiuqing Guo, Jacqueline M. Lane, Jingjing Liang, Xihong Lin, Hao Mei, Sanjay R. Patel, Shaun M. Purcell, Richa Saxena, Neomi A. Shah, Daniel S. Evans, Craig L. Hanis, David R. Hillman, Sutapa Mukherjee, Lyle J. Palmer, Katie L. Stone, Gregory J. Tranah, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Gonçalo R. Abecasis, Eric A. Boerwinkle, Adolfo Correa, L. Adrienne Cupples, Robert C. Kaplan, Deborah A. Nickerson, Kari E. North, Bruce M. Psaty, Jerome I. Rotter, Stephen S. Rich, Russell P. Tracy, Ramachandran S. Vasan, James G. Wilson, Xiaofeng Zhu, Susan Redline, TOPMed Sleep Working Group
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Medicine
Subjects:
Sleep-disordered breathing
Sleep apnea
Whole-genome sequencing
WGS
Genome-wide association study
GWAS
Online Access:https://doi.org/10.1186/s13073-021-00917-8

Internet

https://doi.org/10.1186/s13073-021-00917-8

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