Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Through Fibroblast Dedifferentiation

Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Through Fibroblast Dedifferentiation

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiopathogenesis. The activation of extracellular matrix (ECM)-producing myofibroblasts plays a key role in fibrotic tissue remodeling. The dedifferentiation of myofibroblasts has attracted considerable attention as a promising t...

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Bibliographic Details
Main Authors: Keita Ugai, Shuichi Matsuda, Hideki Mikami, Ayako Shimada, Tomoko Misawa, Hiroyuki Nakamura, Koichiro Tatsumi, Masahiko Hatano, Toshihiko Murayama, Yoshitoshi Kasuya
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
idiopathic pulmonary fibrosis
myofibroblast
dedifferentiation
SET8
UNC0379
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00192/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00192/full

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