Selective Targeting of Human and Animal Pathogens of the <i>Helicobacter</i> Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies

Selective Targeting of Human and Animal Pathogens of the <i>Helicobacter</i> Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies

Antimicrobial resistant (AMR) bacteria constitute a global health concern. <i>Helicobacter pylori</i> is a Gram-negative bacterium that infects about half of the human population and is a major cause of peptic ulcer disease and gastric cancer. Increasing resistance to triple and quadrupl...

Full description

Bibliographic Details
Main Authors: Sandra Salillas, Juan José Galano-Frutos, Alejandro Mahía, Ritwik Maity, María Conde-Giménez, Ernesto Anoz-Carbonell, Helena Berlamont, Adrian Velazquez-Campoy, Eliette Touati, Uwe Mamat, Ulrich E. Schaible, José A. Gálvez, María D. Díaz-de-Villegas, Freddy Haesebrouck, José A. Aínsa, Javier Sancho
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Helicobacter</i>
narrow-spectrum antimicrobial
AMR
flavodoxin
drug discovery
Online Access:https://www.mdpi.com/1422-0067/22/18/10137

Internet

https://www.mdpi.com/1422-0067/22/18/10137

Similar Items