HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

Abstract A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutated viral envelope protein. No vaccin...

Full description

Bibliographic Details
Main Authors: Chelsea N. Fries, Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, Derek W. Cain, Richard Barfield, Cliburn Chan, M. Anthony Moody, Barton F. Haynes, Kevin O. Saunders, Sallie R. Permar, Genevieve G. Fouda, Joel H. Collier
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93702-x

Internet

https://doi.org/10.1038/s41598-021-93702-x

Similar Items