Sample Preparation Strategies for the Effective Quantitation of Hydrophilic Metabolites in Serum by Multi-Targeted HILIC-MS/MS

Sample Preparation Strategies for the Effective Quantitation of Hydrophilic Metabolites in Serum by Multi-Targeted HILIC-MS/MS

The effect of endogenous interferences of serum in multi-targeted metabolite profiling HILIC-MS/MS analysis was investigated by studying different sample preparation procedures. A modified QuEChERS dispersive SPE protocol, a HybridSPE protocol, and a combination of liquid extraction with protein pre...

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Bibliographic Details
Main Authors: Elisavet Tsakelidou, Christina Virgiliou, Lemonia Valianou, Helen G. Gika, Nikolaos Raikos, Georgios Theodoridis
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Metabolites
Subjects:
sample preparation
serum
endogenous metabolites
targeted metabolomics
Online Access:http://www.mdpi.com/2218-1989/7/2/13

Internet

http://www.mdpi.com/2218-1989/7/2/13

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