Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo

Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo

Abstract Background Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and therapeutically-intractable breast cancer; necessitating novel target di...

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Bibliographic Details
Main Authors: Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao, Tse-Hung Huang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Invasive breast cancer
Metastasis
Cancer stem cell
CDH11/β-catenin signaling
miR-335
Antibody therapeutics
Online Access:http://link.springer.com/article/10.1186/s12885-019-5811-1

Internet

http://link.springer.com/article/10.1186/s12885-019-5811-1

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