Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent

Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent

Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release and thus playing a key role in tumor angiogenesis and metastasis. Here we propose new HS analogs as potent heparanase inhib...

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Bibliographic Details
Main Authors: Nicolas Poupard, Pamela Badarou, Fabienne Fasani, Hugo Groult, Nicolas Bridiau, Frédéric Sannier, Stéphanie Bordenave-Juchereau, Claudine Kieda, Jean-Marie Piot, Catherine Grillon, Ingrid Fruitier-Arnaudin, Thierry Maugard
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Marine Drugs
Subjects:
heparanase
angiogenesis
endothelial cells
λ-Carrageenan
hypoxia
anti-angiogenic
sulfated polysaccharide
Online Access:http://www.mdpi.com/1660-3397/15/5/134

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http://www.mdpi.com/1660-3397/15/5/134

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