Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures

Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of the hypothalamus. Several cell biology questions...

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Bibliographic Details
Main Authors: Ruchi Bansal, Staci E. Engle, Patrick J. Antonellis, Logan S. Whitehouse, Anthony J. Baucum, Theodore R. Cummins, Jeremy F. Reiter, Nicolas F. Berbari
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cilia
primary neuronal cultures
hypothalamus
leptin
melanin concentrating hormone receptor 1
hedgehog signaling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00266/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00266/full

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