Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.

Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.

An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation. Alpha toxin (AT), an essential virulence factor for SSTI, has been reported to damage tissue integrity; however its effect on the immune response...

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Bibliographic Details
Main Authors: Christine Tkaczyk, Melissa M Hamilton, Vivekananda Datta, Xiang Ping Yang, Jamese J Hilliard, Geoffrey L Stephens, Agnieszka Sadowska, Lei Hua, Terrence O'Day, JoAnn Suzich, Charles Kendall Stover, Bret R Sellman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788755?pdf=render

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http://europepmc.org/articles/PMC3788755?pdf=render

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