Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway

Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway

In the nervous system, Netrin-1 serves as a neural guide, mediating the neuronal development. However, it remains blurred whether Netrin-1 can protect neurons from apoptosis induced by cerebral stroke. In the current study, the cultured rat primary cortical neurons were transfected with Netrin-1-enc...

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Bibliographic Details
Main Authors: Jianhao Chen, Houwei Du, Yixian Zhang, Hongbin Chen, Mouwei Zheng, Peiqiang Lin, Quan Lan, Qilin Yuan, Yongxing Lai, Xiaodong Pan, Ronghua Chen, Nan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Netrin-1
primary cortical neurons
DNA damage
DCC
ERK
OGD
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00387/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00387/full

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