Molecular Docking and Molecular Dynamics (MD) Simulation of Human Anti-Complement Factor H (CFH) Antibody Ab42 and CFH Polypeptide

Molecular Docking and Molecular Dynamics (MD) Simulation of Human Anti-Complement Factor H (CFH) Antibody Ab42 and CFH Polypeptide

An understanding of the interaction between the antibody and its targeted antigen and knowing of the epitopes are critical for the development of monoclonal antibody drugs. Complement factor H (CFH) is implied to play a role in tumor growth and metastasis. An autoantibody to CHF is associated with a...

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Bibliographic Details
Main Authors: Bing Yang, Shu-Jian Lin, Jia-Yi Ren, Tong Liu, Yue-Ming Wang, Cheng-Ming Li, Wen-Wen Xu, You-Wen He, Wei-Hong Zheng, Jian Zhao, Xiao-Hui Yuan, Hua-Xin Liao
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
complement factor H (CFH)
molecular docking
molecular dynamics (MD) simulation
computational alanine scanning (CAS)
experimental alanine scanning (EAS)
complementarity-determining region (CDR)
Online Access:https://www.mdpi.com/1422-0067/20/10/2568

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https://www.mdpi.com/1422-0067/20/10/2568

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