Synergistic Inhibition of Delayed Rectifier K+ and Voltage-Gated Na+ Currents by Artemisinin in Pituitary Tumor (GH3) Cells

Synergistic Inhibition of Delayed Rectifier K+ and Voltage-Gated Na+ Currents by Artemisinin in Pituitary Tumor (GH3) Cells

Background: Artemisinin (ART) is an anti-malarial agent reported to influence endocrine function. Methods: Effects of ART on ionic currents and action potentials (APs) in pituitary tumor (GH3) cells were evaluated by patch clamp techniques. Results: ART inhibited the amplitude of delayed-rectifier K...

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Bibliographic Details
Main Authors: Edmund Cheung So, Sheng-Nan Wu, Ping-Ching Wu, Hui-Zhen  Chen, Chia-Jung Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Artemisinin
Voltage-gated Na+ current
Delayed-rectifier K+ current
Current kinetics
Action potential
Pituitary cell
Online Access:http://www.karger.com/Article/FullText/475436

Internet

http://www.karger.com/Article/FullText/475436

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