Accurate detection of m6A RNA modifications in native RNA sequences
We currently lack generic methods to map RNA modifications across the entire transcriptome. Here, the authors demonstrate that m6A RNA modifications can be detected with high accuracy using nanopore direct RNA sequencing.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11713-9 |
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doaj-9b36004b41f44913a89a8cca26a8ff72 |
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Article |
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doaj-9b36004b41f44913a89a8cca26a8ff722021-05-11T12:22:51ZengNature Publishing GroupNature Communications2041-17232019-09-011011910.1038/s41467-019-11713-9Accurate detection of m6A RNA modifications in native RNA sequencesHuanle Liu0Oguzhan Begik1Morghan C. Lucas2Jose Miguel Ramirez3Christopher E. Mason4David Wiener5Schraga Schwartz6John S. Mattick7Martin A. Smith8Eva Maria Novoa9Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyDepartment of Physiology and Biophysics, Weill Cornell MedicineDepartment of Molecular Genetics, Weizmann Institute of ScienceDepartment of Molecular Genetics, Weizmann Institute of ScienceDepartment of Neuroscience, Garvan Institute of Medical ResearchSt-Vincent’s Clinical School, UNSW SydneyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyWe currently lack generic methods to map RNA modifications across the entire transcriptome. Here, the authors demonstrate that m6A RNA modifications can be detected with high accuracy using nanopore direct RNA sequencing.https://doi.org/10.1038/s41467-019-11713-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Huanle Liu Oguzhan Begik Morghan C. Lucas Jose Miguel Ramirez Christopher E. Mason David Wiener Schraga Schwartz John S. Mattick Martin A. Smith Eva Maria Novoa |
| spellingShingle |
Huanle Liu Oguzhan Begik Morghan C. Lucas Jose Miguel Ramirez Christopher E. Mason David Wiener Schraga Schwartz John S. Mattick Martin A. Smith Eva Maria Novoa Accurate detection of m6A RNA modifications in native RNA sequences Nature Communications |
| author_facet |
Huanle Liu Oguzhan Begik Morghan C. Lucas Jose Miguel Ramirez Christopher E. Mason David Wiener Schraga Schwartz John S. Mattick Martin A. Smith Eva Maria Novoa |
| author_sort |
Huanle Liu |
| title |
Accurate detection of m6A RNA modifications in native RNA sequences |
| title_short |
Accurate detection of m6A RNA modifications in native RNA sequences |
| title_full |
Accurate detection of m6A RNA modifications in native RNA sequences |
| title_fullStr |
Accurate detection of m6A RNA modifications in native RNA sequences |
| title_full_unstemmed |
Accurate detection of m6A RNA modifications in native RNA sequences |
| title_sort |
accurate detection of m6a rna modifications in native rna sequences |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
We currently lack generic methods to map RNA modifications across the entire transcriptome. Here, the authors demonstrate that m6A RNA modifications can be detected with high accuracy using nanopore direct RNA sequencing. |
| url |
https://doi.org/10.1038/s41467-019-11713-9 |
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