Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function.

Most proteins must remain soluble in the cytosol in order to perform their biological functions. To protect against undesired protein aggregation, living cells maintain a population of molecular chaperones that ensure the solubility of the proteome. Here we report simulations of a lattice model of i...

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Bibliographic Details
Main Authors: William M Jacobs, Tuomas P J Knowles, Daan Frenkel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1004756