The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation

The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation

The cannabinoid receptor CB1 regulates differentiation of spermatids. We recently characterized spermatozoa from <i>caput</i> epididymis of <i>CB1</i>-knock-out mice and identified a considerable number of sperm cells with chromatin abnormality such as elevated histone conten...

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Bibliographic Details
Main Authors: Teresa Chioccarelli, Francesco Manfrevola, Veronica Porreca, Silvia Fasano, Lucia Altucci, Riccardo Pierantoni, Gilda Cobellis
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
estrogens and endocannabinoids
caput and <i>cauda</i> epididymis
type-1 cannabinoid receptor (CB1)
sperm chromatin condensation and maturation
protamine thiol oxidation
chromatin remodeling and histone displacement
Online Access:https://www.mdpi.com/1422-0067/21/9/3117

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https://www.mdpi.com/1422-0067/21/9/3117

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