Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study

Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study

Abstract Objective Spreading depolarizations (SD) are characterized by breakdown of transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate receptor (NMDAR) antagonists block a majority of SDs. In many hospitals, the NMDAR antagonist s-ketamine and the GABAA agonist mida...

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Main Authors: Edgar Santos, Arturo Olivares-Rivera, Sebastian Major, Renán Sánchez-Porras, Lorenz Uhlmann, Kevin Kunzmann, Roland Zerelles, Modar Kentar, Vasilis Kola, Adrian Hernández Aguilera, Mildred Gutierrez Herrera, Coline L. Lemale, Johannes Woitzik, Jed A. Hartings, Oliver W. Sakowitz, Andreas W. Unterberg, Jens P. Dreier
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Critical Care
Subjects:
Stroke
Subarachnoid hemorrhage
Electrocorticography
Neuromonitoring
Ketamine
Spreading depression
Online Access:https://doi.org/10.1186/s13054-019-2711-3

Internet

https://doi.org/10.1186/s13054-019-2711-3

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