Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

Abstract Background Reliable biomarkers of frontotemporal dementia (FTD) are currently lacking. FTD may be associated with chronic immune dysfunction, microglial activation and raised inflammatory markers, particularly in progranulin (GRN) mutation carriers. Levels of soluble triggering receptor exp...

Full description

Bibliographic Details
Main Authors: Ione O. C. Woollacott, Jennifer M. Nicholas, Amanda Heslegrave, Carolin Heller, Martha S. Foiani, Katrina M. Dick, Lucy L. Russell, Ross W. Paterson, Ashvini Keshavan, Nick C. Fox, Jason D. Warren, Jonathan M. Schott, Henrik Zetterberg, Jonathan D. Rohrer
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Cerebrospinal fluid
Frontotemporal dementia
Microglia
Neuroinflammation
Progranulin
TREM2
Online Access:http://link.springer.com/article/10.1186/s13195-018-0405-8

Internet

http://link.springer.com/article/10.1186/s13195-018-0405-8

Similar Items