Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss.

Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss.

Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60-80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzyme that synthesizes gamma-amino butyric acid (GABA)...

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Bibliographic Details
Main Authors: Thashi Chang, Harry Alexopoulos, Philippa Pettingill, Mary McMenamin, Robert Deacon, Ferenc Erdelyi, Gabor Szabó, Camilla J Buckley, Angela Vincent
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3776810?pdf=render

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http://europepmc.org/articles/PMC3776810?pdf=render

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