Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury

Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury

Abstract Background CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage and shedding of the most extracellular domains of CD31 into plasma, enhancing the deleterious effect of neutrophil activatio...

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Main Authors: Quoc Thang Hoang, Alexandre Nuzzo, Liliane Louedec, Sandrine Delbosc, Francesco Andreata, Jamila Khallou-Laschet, Maksud Assadi, Philippe Montravers, Dan Longrois, Olivier Corcos, Giuseppina Caligiuri, Antonino Nicoletti, Jean-Baptiste Michel, Alexy Tran-Dinh
Format: Article
Language:English
Published: SpringerOpen 2018-08-01
Series:Intensive Care Medicine Experimental
Online Access:http://link.springer.com/article/10.1186/s40635-018-0192-3

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http://link.springer.com/article/10.1186/s40635-018-0192-3

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