Design of expert guided investigation of native L-asparaginase encapsulated long-acting cross-linker-free poly (lactic-co-glycolic) acid nanoformulation in an Ehrlich ascites tumor model

Design of expert guided investigation of native L-asparaginase encapsulated long-acting cross-linker-free poly (lactic-co-glycolic) acid nanoformulation in an Ehrlich ascites tumor model

Present study explores native L-asparaginase encapsulated long-acting cross-linker-free PLGA-nanoformulation in an Ehrlich ascites tumor model. L-asparaginase-PLGA nanoparticles for tumor were prepared using a double emulsion solvent evaporation technique, optimized and validated by Box-Behnken Desi...

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Bibliographic Details
Main Authors: Manvi Singh, Nazia Hassan, Devina Verma, Pragya Thakur, Bibhu Prasad Panda, Amulya Kumar Panda, Rakesh Kumar Sharma, Aamir Mirza, Sheikh Mansoor, Salman H. Alrokayan, Haseeb A. Khan, Parvaiz Ahmad, Zeenat Iqbal
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Saudi Pharmaceutical Journal
Subjects:
Chemotherapy
PLGA
L-asparaginase
Box-Behnken Design
Ehrlich ascites tumor (EAT) model
Tumor volume
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016420301006

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http://www.sciencedirect.com/science/article/pii/S1319016420301006

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