Aire downregulation is associated with changes in the posttranscriptional control of peripheral tissue antigens in medullary thymic epithelial cells.

Aire downregulation is associated with changes in the posttranscriptional control of peripheral tissue antigens in medullary thymic epithelial cells.

Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and t...

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Bibliographic Details
Main Authors: Ernna Hérida Oliveira, Claudia Macedo, Cristhianna Viesti Advincula Collares, Ana C. Freitas, Paula B. Donate, Elza T. Sakamoto-Hojo, Eduardo Antonio Donadi, Geraldo Aleixo Passos
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
miRNAs
AIRE
promiscuous gene expression
medullary thymic epithelial cells
miRNA-mRNA Interaction
in vivo gene knockdown.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00526/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00526/full

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