Aire downregulation is associated with changes in the posttranscriptional control of peripheral tissue antigens in medullary thymic epithelial cells.
Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and t...
Main Authors: | Ernna Hérida Oliveira, Claudia Macedo, Cristhianna Viesti Advincula Collares, Ana C. Freitas, Paula B. Donate, Elza T. Sakamoto-Hojo, Eduardo Antonio Donadi, Geraldo Aleixo Passos |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-11-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00526/full |
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