Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1

Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Early stage CRC patients have a good prognosis. If distant metastasis occurs, the 5-year survival drops below 10%. Despite treatment success over the last decades, treatment options for metastatic disease are still limited. Th...

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Bibliographic Details
Main Authors: Dennis Kobelt, Chenyu Zhang, Isabelle Ailish Clayton-Lucey, Rainer Glauben, Cynthia Voss, Britta Siegmund, Ulrike Stein
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
MACC1
metastasis
TNF-α
pro-inflammatory cytokines
colorectal cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00980/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00980/full

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