The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium

The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium

Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cells. A typical feature of CCA is its highly desmoplastic microenvironment containing fibrogenic connective tissue and an abundance of immune cells (T lymphocytes, Natural Killer (NK) cells, and macroph...

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Bibliographic Details
Main Authors: Alessandra Gentilini, Mirella Pastore, Fabio Marra, Chiara Raggi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
cholangiocarcinoma
desmoplastic stroma
tumor microenvironment
tumor-associated macrophages
cancer associated fibroblasts
Online Access:http://www.mdpi.com/1422-0067/19/10/2885

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http://www.mdpi.com/1422-0067/19/10/2885

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