HPOAnnotator: improving large-scale prediction of HPO annotations by low-rank approximation with HPO semantic similarities and multiple PPI networks

HPOAnnotator: improving large-scale prediction of HPO annotations by low-rank approximation with HPO semantic similarities and multiple PPI networks

Abstract Background As a standardized vocabulary of phenotypic abnormalities associated with human diseases, the Human Phenotype Ontology (HPO) has been widely used by researchers to annotate phenotypes of genes/proteins. For saving the cost and time spent on experiments, many computational approach...

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Bibliographic Details
Main Authors: Junning Gao, Lizhi Liu, Shuwei Yao, Xiaodi Huang, Hiroshi Mamitsuka, Shanfeng Zhu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Medical Genomics
Subjects:
Low-rank approximation
Human phenotype ontology
Protein-protein interaction networks
Hierarchical structure
Online Access:https://doi.org/10.1186/s12920-019-0625-1

Internet

https://doi.org/10.1186/s12920-019-0625-1

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