BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production.

BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production.

Bone morphogenetic proteins (BMPs) and their receptors, such as bone morphogenetic protein receptor (BMPR) II, have been implicated in a wide variety of disorders including pulmonary arterial hypertension (PAH). Similarly, endothelin-1 (ET-1), a mitogen and vasoconstrictor, is upregulated in PAH and...

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Bibliographic Details
Main Authors: John E S Park, Dongmin Shao, Paul D Upton, Patricia Desouza, Ian M Adcock, Rachel J Davies, Nicholas W Morrell, Mark J D Griffiths, Stephen J Wort
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3267722?pdf=render

Internet

http://europepmc.org/articles/PMC3267722?pdf=render

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