Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and inflammation in a rat paw edema model

Bibliographic Details
Main Authors: Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer, David P. Fairlie
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00414-w