COFACTOR SPECIFICITY ENGINEERING OF STREPTOCOCCUS MUTANS NADH OXIDASE 2 FOR NAD(P)+ REGENERATION IN BIOCATALYTIC OXIDATIONS

COFACTOR SPECIFICITY ENGINEERING OF STREPTOCOCCUS MUTANS NADH OXIDASE 2 FOR NAD(P)+ REGENERATION IN BIOCATALYTIC OXIDATIONS

Soluble water-forming NAD(P)H oxidases constitute a promising NAD(P)+ regeneration method as they only need oxygen as cosubstrate and produce water as sole byproduct. Moreover, the thermodynamic equilibrium of O2 reduction is a valuable driving force for mostly energetically unfavorable biocatalytic...

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Bibliographic Details
Main Authors: Barbara Petschacher, Nicole Staunig, Monika Müller, Martin Schürmann, Daniel Mink, Stefaan De Wildeman, Karl Gruber, Anton Glieder
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Computational and Structural Biotechnology Journal
Subjects:
coenzyme selectivity
NADPH recycling
2-heptanol oxidation
NADPH oxidase
site-directed mutagenesis
cofactor regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014600088

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http://www.sciencedirect.com/science/article/pii/S2001037014600088

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