Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner

Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner

Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue (WAT) of 8-week-old male and female mouse offspring. Methods: C57BL/6J fe...

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Bibliographic Details
Main Authors: Josca M. Schoonejans, Heather L. Blackmore, Thomas J. Ashmore, Catherine E. Aiken, Denise S. Fernandez-Twinn, Susan E. Ozanne
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
gestational diabetes
foetal programming
metformin
maternal obesity
white adipose tissue
sex differences
Online Access:https://www.mdpi.com/1422-0067/22/15/8104

Internet

https://www.mdpi.com/1422-0067/22/15/8104

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