Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors

Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors

Abstract Background Triple negative breast cancer (TNBC) is an aggressive neoplasia with no effective therapy. Our laboratory has developed a unique TNBC cell model presenting epithelial mesenchymal transition (EMT) a process known to be important for tumor progression and metastasis. There is incre...

Full description

Bibliographic Details
Main Authors: Yanrong Su, Nathan R. Hopfinger, Theresa D. Nguyen, Thomas J. Pogash, Julia Santucci-Pereira, Jose Russo
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Triple negative breast cancer
Epithelial mesenchymal transition
DNA methyltransferase
Histone deacetylase
Online Access:http://link.springer.com/article/10.1186/s13046-018-0988-8

Internet

http://link.springer.com/article/10.1186/s13046-018-0988-8

Similar Items