Thymidine Phosphorylase Expression and Microvascular Density Correlation Analysis in Canine Mammary Tumor: Possible Prognostic Factor in Breast Cancer

Thymidine Phosphorylase Expression and Microvascular Density Correlation Analysis in Canine Mammary Tumor: Possible Prognostic Factor in Breast Cancer

Purpose: The thymidine phosphorylase (TP) is a key enzyme involved in the metabolism of pyrimidines. Inhibition or downregulation of this enzyme causes accumulation of metabolites with consequences in DNA replication. TP regulates angiogenesis and chemotactic activity of endothelial cells. Different...

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Bibliographic Details
Main Authors: Nicola Zizzo, Giuseppe Passantino, Roberta Maria D'alessio, Antonella Tinelli, Giuseppe Lopresti, Rosa Patruno, Domenico Tricarico, Fatima Maqoud, Rosa Scala, Francesco Alfredo Zito, Girolamo Ranieri
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Veterinary Science
Subjects:
canine mammary tumor
thymidine phosphorylase
histopathology
microvasculature
cell proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2019.00368/full

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https://www.frontiersin.org/article/10.3389/fvets.2019.00368/full

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