Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Abstract Background 18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to contain negligible concentrations of PHF raise questions about the interpretation of the positron e...

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Bibliographic Details
Main Authors: Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier, Pedro Rosa-Neto
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
18F-THK5351 tau tracer
Monoamine oxidase-B
Selegiline
Alzheimer’s disease
Positron emission tomography
Online Access:http://link.springer.com/article/10.1186/s13195-017-0253-y

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http://link.springer.com/article/10.1186/s13195-017-0253-y

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