Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467

Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467

Background/Aims: This study determined the role and mechanism of action of transcription factor EB (TFEB) in H2O2-induced neuronal apoptosis. Methods: SH-SY5Y cells were treated with Akt inhibitor/activator and different concentrations of H2O2. Cell apoptosis was detected by flow cytometric analysis...

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Bibliographic Details
Main Authors: Qian Su, Bin Zheng, Chen-yao Wang, Yun-zhi Yang, Wen-wen Luo, Shu-min Ma, Xin-hua Zhang, Dong Ma, Yan Sun, Zhan Yang, Jin-kun Wen, Zhi-xue Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Tfeb
Akt signalling
Phosphorylation
Oxidative stress
SH-SY5Y cell
Neuronal apoptosis
Online Access:https://www.karger.com/Article/FullText/489198

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https://www.karger.com/Article/FullText/489198

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