A cell permeable peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat model.

A cell permeable peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat model.

Cell permeable peptides (CPP) aid cellular uptake of targeted cargo across the hydrophobic plasma membrane. CPP-mediated cargo delivery of receptor signaling motifs provides an opportunity to regulate specific receptor initiated signaling cascades. Both endothelin-1 receptors, ETA and ETB, have been...

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Bibliographic Details
Main Authors: Daniel S Green, Chamila Rupasinghe, Rod Warburton, Jamie L Wilson, Christine O Sallum, Linda Taylor, Achani Yatawara, Dale Mierke, Peter Polgar, Nicholas Hill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842336?pdf=render

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http://europepmc.org/articles/PMC3842336?pdf=render

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