Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients

Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients

Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug...

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Bibliographic Details
Main Authors: Raquel Lima de Figueiredo Teixeira, Renata Gomes Morato, Pedro Hernan Cabello, Ligia Mayumi Kitada Muniz, Adriana da Silva Rezende Moreira, Afrânio Lineu Kritski, Fernanda Carvalho Queiroz Mello, Philip Noel Suffys, Antonio Basilio de Miranda, Adalberto Rezende Santos
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2011-09-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
hepatotoxicity
tuberculosis
isoniazid
NAT2
CYP2E1
GSTM1
GSTT1
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600011&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000600011&lng=en&tlng=en

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