Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipoc...

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Bibliographic Details
Main Authors: Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, Natalie N. Walker, Stefan R. Hargett, Scott A. Seaman, Shayn M. Peirce-Cottler, Brant E. Isakson, Coleen A. McNamara, Susanna R. Keller, Thurl E. Harris, Douglas A. Bayliss, Norbert Leitinger
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Molecular Metabolism
Subjects:
Pannexin 1
Adipocyte
Extracellular ATP
Glucose uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001337

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http://www.sciencedirect.com/science/article/pii/S2212877815001337

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