Gene mining-based identification of aldo–keto reductases for highly stereoselective reduction of bulky ketones

Gene mining-based identification of aldo–keto reductases for highly stereoselective reduction of bulky ketones

Abstract Background Aldo–keto reductase (AKR) or alcohol dehydrogenases (ADH)-mediated stereoselective reduction of prochiral carbonyl compounds is an efficient way of preparing single enantiomers of chiral alcohols. However, steric hindrance of substrate affects the catalytic performance of enzymes...

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Bibliographic Details
Main Authors: Chen Liang, Yao Nie, Xiaoqing Mu, Yan Xu
Format: Article
Language:English
Published: SpringerOpen 2018-07-01
Series:Bioresources and Bioprocessing
Subjects:
Aldo–keto reductase
Carbonyl compound
Gene mining
Stereoselectivity
Substrate specificity
Online Access:http://link.springer.com/article/10.1186/s40643-018-0220-x

Internet

http://link.springer.com/article/10.1186/s40643-018-0220-x

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