Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21

Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21

Background:CXorf21 and SLC15a4 both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the protein products of these genes, which form a c...

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Bibliographic Details
Main Authors: Valerie M. Harris, Isaac T. W. Harley, Biji T. Kurien, Kristi A. Koelsch, Robert Hal Scofield
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
Sjögren's syndrome
lysosome
pH
X chromosome
sex bias
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00578/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00578/full

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