Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Myeloid cells are implicated in the innate immune and inflammatory response during infection with Chlamydia trachomatis. Here the authors show the evasion of the neutrophil response to infection and concomitant induction of sterile immunity via the purinergic P2X7 receptor.

Bibliographic Details
Main Authors: Chunfu Yang, Lei Lei, John W. Marshall Collins, Michael Briones, Li Ma, Gail L. Sturdevant, Hua Su, Anuj K. Kashyap, David Dorward, Kevin W. Bock, Ian N. Moore, Christine Bonner, Chih-Yu Chen, Craig A. Martens, Stacy Ricklefs, Masahiro Yamamoto, Kiyoshi Takeda, Yoichiro Iwakura, Grant McClarty, Harlan D. Caldwell
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25749-3

Internet

https://doi.org/10.1038/s41467-021-25749-3

Similar Items