Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. The...

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Bibliographic Details
Main Authors: Samanta C. Funes, Mariana Rios, Ayleen Fernández-Fierro, Camila Covián, Susan M. Bueno, Claudia A. Riedel, Juan Pablo Mackern-Oberti, Alexis M. Kalergis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01467/full