Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome

Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome

Abstract Background Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is used for the treatment of type 2 diabetes and was reported to exert the...

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Bibliographic Details
Main Authors: Eun Kyung Kim, Hong Ki Min, Seon-Yeong Lee, Da-Som Kim, Jun-Geol Ryu, Hyun Sik Na, Kyoung Ah Jung, Jeong Won Choi, Sung-Hwan Park, Mi-La Cho
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Obesity
Mitochondria
Metformin
Rapamycin
Online Access:http://link.springer.com/article/10.1186/s13075-020-02174-3

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http://link.springer.com/article/10.1186/s13075-020-02174-3

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