Anti-aggregant tau mutant promotes neurogenesis

Anti-aggregant tau mutant promotes neurogenesis

Abstract Background The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-a...

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Bibliographic Details
Main Authors: Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Hippocampus
CA3
Neurogenesis
Wnt
Online Access:http://link.springer.com/article/10.1186/s13024-017-0230-8

Internet

http://link.springer.com/article/10.1186/s13024-017-0230-8

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