Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence

Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence

Background: In multiple sclerosis loss of myelin and oligodendrocytes impairs saltatory signal transduction and leads to neuronal loss and functional deficits. Limited capacity of oligodendroglial precursor cells to differentiate into mature cells is the main reason for inefficient myelin repair in...

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Bibliographic Details
Main Authors: Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M. Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P. Antel, Hans-Peter Hartung, Patrick Küry
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:EBioMedicine
Subjects:
Remyelination
CDKN1C
Nuclear protein shuttling
Drug repurposing
Cell differentiation
Toxin-mediated demyelination
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000694

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http://www.sciencedirect.com/science/article/pii/S2352396421000694

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