Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

Neurotropic strains of mouse hepatitis virus (MHV) induce acute inflammation and chronic demyelination in the spinal cord and optic nerves mediated by axonal spread following intracranial inoculation in mice, with pathologic features similar to the human demyelinating disease multiple sclerosis. Spi...

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Bibliographic Details
Main Authors: Manmeet Singh, Reas S. Khan, Kimberly Dine, Jayasri Das Sarma, Kenneth S. Shindler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
optic neuritis
demyelination
mouse hepatitis virus
intranasal inoculation
intracranial inoculation
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00311/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00311/full

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