Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury

Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury

Abstract Background The acute phase response (APR) to CNS insults contributes to the overall magnitude and nature of the systemic inflammatory response. Aspects of this response are thought to drive secondary inflammatory pathology at the lesion site, and suppression of the APR can therefore afford...

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Bibliographic Details
Main Authors: Abi G. Yates, Trisha Jogia, Ellen R. Gillespie, Yvonne Couch, Marc J. Ruitenberg, Daniel C. Anthony
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Neurotrauma
Systemic inflammatory response syndrome
Acute phase response
IL-1 receptor antagonist
Neutrophils
Macrophage
Online Access:https://doi.org/10.1186/s12974-020-02050-6

Internet

https://doi.org/10.1186/s12974-020-02050-6

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