Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients.

Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients.

Toll-like receptor (TLR) agonists can reactivate HIV from latently infected cells in vitro. We aimed to investigate the TLR-9 agonist, CPG 7909's in vivo effect on the proviral HIV reservoir and HIV-specific immunity. This was a post-hoc analysis of a double-blind randomized controlled vaccine...

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Bibliographic Details
Main Authors: Anni A Winckelmann, Lærke V Munk-Petersen, Thomas A Rasmussen, Jesper Melchjorsen, Thomas J Hjelholt, David Montefiori, Lars Østergaard, Ole S Søgaard, Martin Tolstrup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3637371?pdf=render

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http://europepmc.org/articles/PMC3637371?pdf=render

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