Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

Early trauma and stress exposure during a critical period of life may increase the risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) in adulthood. The first-choice treatment for MDD and PTSD are selective serotonin reuptake inhibitor (SSRI) antidepressants. Unfortunat...

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Bibliographic Details
Main Authors: Andrea Locci, Philippe Geoffroy, Michel Miesch, Ayikoe-Guy Mensah-Nyagan, Graziano Pinna
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
early stress
depression
PTSD
pharmacoresistance
allopregnanolone
GABAA receptors
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00208/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00208/full

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