Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies

Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies

The adoptive transfer of chimeric antigen receptor T (CAR T) cells have been recognized as a promising therapeutic strategy for the treatment of hematological malignancies; however, clinical success using CAR T cells for the treatment of solid tumors are still limited since the T-cell function is in...

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Bibliographic Details
Main Authors: Shouheng Lin, Lin Cheng, Wei Ye, Shanglin Li, Diwei Zheng, Le Qin, Qiting Wu, Youguo Long, Simiao Lin, Suna Wang, Guohua Huang, Peng Li, Yao Yao, Xiaofang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
CAR-T
CTLA4
CD80
CD86
myeloid-derived suppressor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642528/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.642528/full

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